HOW ALCOHOL ATTACKS THE BRAIN A guide to the sequential damage alcohol inflicts on neural tissue 1. First, alcohol affects the forebrain and assaults motor coordination and decision making. 2. Then, alcohol knocks out the midbrain, and you lose control over emotions and increase chances of a blackout. 3. Finally, alcohol batters the brainstem as it affects heart rate, body temperature, appetite and consciousness, a dangerous and potentially fatal condition. The image features a diagram of a human brain with three red arrows pointing to specific regions: the forebrain, midbrain, and brainstem.